The endocrine disorder is regularly very perplexing, including a blended picture of hyposecretion and hypersecretion due to the input components associated with the endocrine framework. For instance, most types of hyperthyroidism are related with an overabundance of thyroid hormone and a low level of thyroid animating hormone. Patients with multi-transfused thalassemia major may create serious endocrine complexities due to iron overload. The anterior pituitary is especially sensitive to iron overloaded which upsets hormonal emission resulting in hypogonadism, short stature, acquired hypothyroidism, and hypoparathyroidism. Glucose intolerance and diabetes mellitus are additionally regular in thalassaemic patients.